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Event Type:  Seminar (This is an NIH Science event)
Title:  IIG Seminar Series - Golnaz Vahedi (UPenn) - "Genetic predisposition to type 1 diabetes leads to chromatin misfolding"
Description:  Golnaz Vahedi, Ph.D.
Assistant Professor of Genetics
Member, Institute for Immunology - Core member, Epigenetics Institute
Perelman School of Medicine - University of Pennsylvania

“Genetic Predisposition to Type 1 Diabetes Leads to Chromatin Misfolding”

Wednesday, March 27th 2019
Lipsett Auditorium, Bldg. 10

Host: John O’Shea (NIAMS)

Type 1 diabetes (T1D) is a chronic metabolic disorder characterized by the autoimmune destruction of insulin-producing beta cells in genetically predisposed individuals. Genome-wide association studies have identified risk regions across the human genome, marked by single nucleotide polymorphisms (SNPs). Numerous reports exploiting the linear and three-dimensional (3D) chromatin organization data in immune cells of healthy individuals postulate that disease-associated SNPs can alter gene expression through spatial interactions of distal loci. However, it remains unclear if genetic predisposition can lead to chromatin misfolding in type 1 diabetes. We found that while linear and 3D genome organizations at T cell identity genes are resilient to natural genetic variations, genetic predisposition to type 1 diabetes can create de novo chromatin misfolding.

Short biography:
Golnaz Vahedi received her B.Sc. degree in Electrical Engineering from Sharif University of Technology, Tehran, Iran in 2001 and her Ph.D. degree with Dr. Edward R. Doughertyand Dr. Jean-Francois Chamberland in Electrical Engineering from Texas A&M University in 2009. She then joined the laboratory of Dr. John O'Shea at the NIH as a postdoctoral fellow to study the epigenomics aspects of T cells. She started her independent lab at the Department of Genetics of the University of Pennsylvania in May 2015. Her research interest spans the areas of computational biology, bioinformatics, machine learning, human genetics, chromatin biology, and immunology. She is the recipient of number of awards incl
Series Name:  IIG Seminar Series
Videocast:  Event will be videocast LIVE on the Web
Videocast URL:
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Wednesday, March 27, 2019   4:15pm - 5:30pm Add To Outlook Calendar     Add To iCal Calendar     Add To Entourage Calendar
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Name:   Golnaz Vahedi

Organization(s):  [NIH] Immunology Interest Group

Location:  On the main NIH Campus
Building:  Building 10 (Clinical Center)
Room:  Lipsett Auditorium
Street Address:  10 Center Drive
City:  Bethesda
State:  Maryland
Zip Code:  20892

Name:   Gregoire Altan-Bonnet
Phone:   240-760-6888
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