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Event Type:  Seminar (This is an NIH Science event)
Title:  Neurobiology Interest Group Seminar Series: "Neocortical projection neurons instruct inhibitory interneuron circuit development in a lineage dependent manner"
Description:  Neocortical circuits consist of stereotypical motifs that must self-assemble during development. Excitatory projection neurons (PNs) can be segregated based on the target of their long-range axonal targets: intratelencephalic (IT) PNs target cortex/striatum while pyramidal tract (PT) PNs target the midbrain, brainstem, and spinal cord. Their output is regulated by inhibitory interneurons (INs), which can also be segregated into two non-overlapping subgroups, based on their embryonic lineage from either the caudal or medial ganglionic eminences (CGE and MGE). Recent evidence suggests that PNs influence the postnatal development of INs, possibly in a subtype-dependent manner. We knocked out the transcription factor Satb2 in PNs to induce those of the IT-type to adopt a PT-type identity. Loss of IT PNs disrupted the lamination and molecular expression profile of INs derived selectively from CGE, in a subtype specific manner. Furthermore, reprogrammed PNs demonstrated altered connectivity with local CGE INs, with a striking reduction in synaptic targeting of all subtypes. In deep layers of control mice, where IT and PT PNs are intermingled, IT PNs targeted neighboring CGE INs while PT PNs did not, confirming this lineage-dependent motif. Our data show that both PN class and IN embryonic lineage are important general variables during the construction of cortical circuits.

Meeting number: 621 968 205
Meeting password: KmE9xVZT
Meeting link:
Host key: 795707
Series Name:  Neurobiology Interest Group Seminar Series
Event URL:
Videocast:  Event will not be videocast
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Thursday, July 19, 2018   3:30pm - 5:00pm Add To Outlook Calendar     Add To iCal Calendar     Add To Entourage Calendar
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Name:   Jason Wester
Title:   PhD
Organization:   NICHD
City/Province:   Bethesda
State:   Maryland
Country:   United States

Organization(s):  [NIH] Neurobiology Interest Group

Location:  On the main NIH Campus
Building:  35
Room:  610

Name:   Richa Lomash
Name:   Shireen Sarraf
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