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EVENT DESCRIPTION  
 
Event Type:  Lecture (This is an NIH Science event)
 
Annual Lecture:  Other
 
Title:  Robert Best, Ph.D., NIDDK, "Molecular simulation tools for investigating structure and dynamics of intrinsically disordered proteins"
 
Description:  Intrinsically disordered proteins (IDPs) are increasingly realized to play a wide range of functional as well as pathological roles in biology. However, biophysical characterization of these proteins is experimentally challenging due to the extremely heterogeneous ensemble of structures which they populate. Computational tools, in particular molecular simulations, can therefore play a role in elucidating structure, function and dynamics in IDPs. Here, Dr. Best will show how both detailed atomistic simulations, as well as simplified coarse-grained models can be used to assist in the interpretation of experiments on IDPs. In particular, Dr. Best will describe recent work characterizing an ultra-high affinity complex between two charged IDPs which, remarkably, remain completely disordered upon binding.
 
Series Name:  NIH Director's Seminar Series
 
Videocast:  Event will be videocast LIVE on the Web
 
Videocast URL:  http://videocast.nih.gov
  Event will be available in the videocast ARCHIVE
 
Special Instructions:  To arrange sign language interpretation for an event go to the Office
of Research Services (ORS) Interpreting Service Requests web page.
 

EVENT DATE/TIME  
 
Date/Time: 
Friday, June 01, 2018   12:00pm - 1:00pm Add To Outlook Calendar     Add To iCal Calendar     Add To Entourage Calendar
 
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EVENT SPEAKER(S)  
 
Name:   Robert Best, Ph.D
Title:   Senior Investigator
Organization:   Laboratory of Chemical Physics, NIDDK
 

EVENT SPONSOR(S)  
 
Organization(s):  [NIH] Office of the Director (OD)
 

EVENT LOCATION  
 
Location:  On the main NIH Campus
Building:  Building 1
Room:  Wilson Hall, 3rd Floor
 
Street Address:  1 Center Drive
City:  Bethesda
State:  Maryland
Zip Code:  20892
 

EVENT CONTACT(S)  
 
Name:   Margaret McBurney
E-mail:   mmcburney@od.nih.gov
Phone:   (301) 496-1921
 
 
 
 
 
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