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Event Type:  Seminar (This is an NIH Science event)
Title:  micro-CT: A versatile tool for human disease modelling in Drosophila melanogaster
Description:  Microcomputed tomography (µ-CT) has emerged as a useful imaging technique in vertebrate models of human disease, allowing for nondestructive imaging of intact organisms that preserves tissues in their native biological environment. Recently, there has been a renewed interest in using the fruit fly (Drosophila melanogaster) to model various human diseases, given that ~75% of all human disease genes are conserved in these tiny insects. Flies offer a number of advantages that allow for a mechanistic understanding of disease. These include a sophisticated array of genetic tools and the ability to visualize tissues using classic light microscopy-based techniques, such as confocal laser scanning microscopy. However, there are certain limitations regarding the use of these techniques, particularly for the observation of diseased tissue. In this seminar, I will introduce µ-CT as a useful imaging tool in Drosophila that overcomes these limitations, particularly as it relates to models of human disease. I will present a brief overview of the technique, an optimized labeling protocol and proof of principle experiments that showcase how we have been able to successfully model human microcephaly and cardiomyopathies in the fly. Our findings validate µ-CT as a versatile tool for imaging Drosophila and highlights its usefulness in the realm of hypothesis-driven research, rather than serving solely as a platform for descriptive analysis of morphology.
Series Name:  MIF Seminars
Videocast:  Event will not be videocast
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Wednesday, May 09, 2018   1:00pm - 2:00pm Add To Outlook Calendar     Add To iCal Calendar     Add To Entourage Calendar
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Name:   Todd Schoborg, PhD
Title:   Postdoctoral Fellow
Organization:   Nasser Rusan Lab, NHBLI

Organization(s):  NIH Mouse Imaging Facility -

Location:  On the main NIH Campus
Building:  Building 10
Room:  B1D-55
Street Address:  10 Center Drive
City:  Bethesda
State:  Maryland
Zip Code:  20892
Other Information:  Starting at Masur Auditorium in building 10, go down to the B1 level and look for the signs directing you to the NIH NMR Research Center (left side if B1 cafeteria behind you). Follow them down the D corridor (lined with artwork) to the NMR Center. B1D-55 will be on the left near the vending machines.

Name:   Brenda Klaunberg
Phone:   301-594-3898
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