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EVENT DESCRIPTION  
 
Event Type:  Seminar (This is an NIH Science event)
 
Title:  Neurobiology Interest Group Seminar Series: Natural and artificial hunger gate orthogonal behavioral choice
 
Description:  Hunger is one of the most salient need states across the animal kingdom, crucially impacting motivated behavior. Numerous findings suggest Agouti-related peptide (AgRP)-expressing neurons in the arcuate nucleus of the hypothalamus are vital to mammalian calorie-sensing and directing subsequent motivated behaviors to consume caloric substrates. Not much attention has been paid, however, to how these neurons’ activity may impact unrelated motivated behaviors. Here, we sought to investigate how hunger states may influence an animal’s pursuit of motivated behaviors unassociated with feeding, using ARCAgRP neurons as an entry point to hunger states. Using optogenetics, we demonstrate that ARCAgRP neuron stimulation provokes hunger-like behaviors mimicking overall tendencies of naturally hungry animals. Upon closer investigation using more ethologically relevant behavior assays, we observed artificial stimulation has striking effects on animals’ motivation to engage with multiple salient stimuli at once; these effects are seen only in extreme natural hunger states. Surprisingly, using fiber photometry recording methods, we also observed that ARCAgRP neurons dynamically alter their firing in response to a social conspecific. This suggests ARCAgRP neurons, and hunger more broadly, exhibit a highly complicated neural interface with processes governing other motivated behaviors.

JOIN WEBEX MEETING
https://nih.webex.com/nih/j.php?MTID=ma1aa7e269847c048b9f69f4e9ab21b25
Meeting number (access code): 627 725 612
Meeting password: gf28CEpJ
 
Series Name:  Neurobiology Interest Group Seminar Series
 
Event URL:  https://oir.nih.gov/sigs/neurobiology-interest-group
 
Videocast:  Event will not be videocast
 
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EVENT DATE/TIME  
 
Date/Time: 
Thursday, May 03, 2018   3:30pm - 5:00pm Add To Outlook Calendar     Add To iCal Calendar     Add To Entourage Calendar
 
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EVENT SPEAKER(S)  
 
Name:   Joey Burnett
Organization:   NIDDK
City/Province:   Bethesda
State:   Maryland
 

EVENT SPONSOR(S)  
 
Organization(s):  [NIH] Neurobiology Interest Group
 

EVENT LOCATION  
 
Location:  On the main NIH Campus
Building:  35
Room:  620/630
 
 

EVENT CONTACT(S)  
 
Name:   Richa Lomash
E-mail:   richa.madanlomash@nih.gov
 
Name:   Shireen Sarraf
E-mail:   shireen.sarraf@nih.gov
 
 
 
 
 
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