Skip Navigation
Click Subscribe to join the NIH Calendar of Events e-mail list or Sign In to add or modify your events.  

Event Details

    E-mail this page E-mail this page

Event Type:  Seminar (This is an NIH Science event)
Title:  Mitophagy and inflammation: Connecting mitochondrial dysfunction and neurodegeneration
Description:  Although serum from Parkinson’s disease (PD) patients displays elevated levels of numerous pro-inflammatory cytokines including IL-6, TNFa, IL-1ß, and IFNg, whether inflammation contributes to or is a consequence of neuronal loss remains unknown1. Mutations in Parkin, an E3 ubiquitin ligase, and PINK1, a ubiquitin kinase, cause early-onset PD2,3. Working in the same biochemical pathway, PINK1 and Parkin remove damaged mitochondria from cells in culture and in animal models via a selective form of autophagy, called mitophagy4. The role of mitophagy in vivo, however, is unclear in part because mice lacking PINK1 or Parkin have no substantial PD-relevant phenotypes, in contrast to man and Drosophila 5-7. As mitochondrial stress can lead to the release of damage-associated molecular patterns (DAMPs) that can activate innate immunity8-14, we examined if mitophagy may mitigate inflammation. Here we report a strong inflammatory phenotype in both Parkin-/- and PINK1-/- mice following exhaustive exercise (EE) and in Parkin-/-;Mutator mice, which accumulate mitochondrial DNA mutations with age15. Inflammation resulting from both EE and mtDNA mutation is completely rescued by concurrent loss of STING, a central regulator of the Type-I Interferon response to cytosolic DNA16,17. A motor defect observed in aged Parkin-/-; Mutator mice is also rescued by loss of STING, suggesting that inflammation facilitates this phenotype. These results support an unanticipated function for PINK1- and Parkin-mediated mitophagy and a novel link to PD.
Series Name:  Neurobiology Interest Group Seminar Series
Event URL:
Videocast:  Event will not be videocast
Special Instructions:  To arrange sign language interpretation for an event go to the Office
of Research Services (ORS) Interpreting Service Requests web page.

Wednesday, April 04, 2018   3:30pm - 5:00pm Add To Outlook Calendar     Add To iCal Calendar     Add To Entourage Calendar
  Click on MS Outlook Calendar Icon (MS Outlook) or Mac iCal Calendar Icon (Mac iCal) or Entourage Calendar Icon (MS Entourage for MAC) to add an event into your Calendar. Need Help?

Name:   Danielle Sliter
Title:   PhD
Organization:   NINDS
City/Province:   Bethesda
State:   Maryland

Organization(s):  [NIH] Neurobiology Interest Group

Location:  On the main NIH Campus
Building:  35
Room:  640

Name:   Richa Lomash
Name:   Shireen Sarraf
View by: Day | Week | Month | Year

Calendar Home Page | Feedback | NIH Home Page