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EVENT DESCRIPTION  
 
Event Type:  Seminar (This is an NIH Science event)
 
Title:  Combination of cryo-EM and genetics for studying eukaryotic cilia
 
Description:  Eukaryotic cilia are complex cell organelles and play important roles in various cell, such as propeller and antenna. They consist of hundreds of different proteins that are precisely organized by self-assembly mechanisms. To study such a complex system, we combine genetics and structural biology. We have been identifying 3D locations of specific proteins by combining Chlamydomonas genetics and cryo-electron tomography (cryo-ET)[1-3]. We have recently started using zebrafish and mice as model organisms for studying cilia, to which we can apply genome editing techniques. These new approaches enable us to identify and characterize new ciliary proteins.
[1] Oda T., H. A. Yanagisawa, R. Kamiya, and M. Kikkawa “A molecular ruler determines the repeat length in eukaryotic cilia and flagella” Science, 346:857-860, 2014
[2] Oda T., T. Abe, H. A. Yanagisawa, and M. Kikkawa “Structure and function of outer dynein arm intermediate and light chain complex”, Molecular Biology of the Cell, 27:1051-9, 2016
[3] Oda T., T. Abe, H. A. Yanagisawa, and M. Kikkawa
Docking complex-independent alignment of outer dynein arms with 24-nm periodicity in vitro.
Journal of Cell Science, 129:1547-51, 2016
 
Videocast:  Event will not be videocast
 
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EVENT DATE/TIME  
 
Date/Time: 
Wednesday, March 07, 2018   11:00am - 12:00pm Add To Outlook Calendar     Add To iCal Calendar     Add To Entourage Calendar
 
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EVENT SPEAKER(S)  
 
Name:   Masahide Kikkawa
Title:   Professor
Organization:   Department of Cell Biology and Anatomy, Graduate School of Medicine,
City/Province:   Tokyo
Country:   Japan
 

EVENT SPONSOR(S)  
 
Organization(s):  LCMB/NIDDK
 

EVENT LOCATION  
 
Location:  On the main NIH Campus
Building:  8
Room:  127
 
Street Address:  8 Center Drive
City:  Bethesda
State:  Maryland
Zip Code:  20892
 

EVENT CONTACT(S)  
 
Name:   Jenny Hinshaw
E-mail:   jennyh@niddk.nih.gov
Phone:   3015940842
 
 
 
 
 
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