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Event Type:  Lecture (This is an NIH Science event)
Title:  Effectors versus Protectors: How Anti-inflammatory Tissue Macrophages Maintain Tissue Homeostasis
Description:  Dr. Stefan Uderhardt is a post-doctoral fellow in Dr. Ronald Germain's group within the Laboratory of Systems Biology (LSB), NIAID. Stefan received his medical degree (Dr. med.) from the University of Erlangen-Nürnberg, Germany in 2011. Early during medical school he developed a passion for immunological research, and thus spent most his spare time working on an experimental thesis on osteoimmunology in the lab of Georg Schett and Gerhard Krönke, investigating the mechanisms of bone loss during inflammatory arthritis. He then started a residency in rheumatology and clinical immunology at the University Hospital Erlangen, while still continuing his active bench work with research on pro- and anti-inflammatory macrophage functions in the context of clearance of apoptotic cells.
In 2014, after 3 years of hospital work, he decided to pause his clinical training and join Dr. Germain's lab to intensify his scientific training in immunology with focus on different imaging techniques. In Dr. Germain's lab, he developed a new intravital imaging platform, which enabled him to study different innate immune populations and their interactions under inflammatory conditions in vivo in exceptional detail. Using intravital and static multi-parameter imaging, he identified a multi-layered regulation of the initial steps in an inflammatory response to tissue damage, comprising concerted action by tissue-resident and recruited immune cells. Specifically, he found that tissue-resident macrophages, displaying an anti-inflammatory expression profile by default, actively regulate inflammatory neutrophil activation and swarming in response to tissue damage, thereby fine-tuning the threshold for onset of damaging inflammation in peripheral tissues. His work provides novel insights in mechanisms of host defense and tissue protection, and introduces potential new aspects in the treatment and management of inflammatory diseases. Stefan is a superb photographer, and his ‘eye’ has led him to ge
Series Name:  IIG seminar Series
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Videocast:  Event will be videocast LIVE on the Web
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Wednesday, January 24, 2018   4:15pm - 5:15pm Add To Outlook Calendar     Add To iCal Calendar     Add To Entourage Calendar
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Name:   Stefan Uderhardt, MD
Title:   Postdoctoral Fellow
Organization:   NIAID
City/Province:   Bethesda
State:   Maryland

Organization(s):  [NIH] Immunology Interest Group

Location:  On the main NIH Campus
Building:  Bldg. 10
Room:  Lipsett Auditorium,
Street Address:  10 Center Drive
City:  Bethesda
State:  Maryland
Zip Code:  20892

Name:   Niki Moutsopoulos
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