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Event Type:  Seminar (This is an NIH Science event)
Annual Lecture:  Other
Title:  One TOG, Two TOG: Regulation of microtubule dynamics by TOG-domain proteins
Description:  performance of crystallographic refinement by adopting an algorithm from engineering disciplines that allowed more effective conformational sampling.
Dr. Rice stayed at Yale for his graduate studies in the Department of Molecular Biophysics and Biochemistry, continuing to work with Axel Brunger. His graduate work was mostly focused on biophysical and structural studies of yeast vesicular transport proteins (SNAREs and ?-SNAP).
During his postdoctoral work with David Agard at UC San Francisco, Dr. Rice determined atomic structures of ?-tubulin, a specialized tubulin that catalyzes microtubule initiation in vivo. These and other experiments provided new insights into the mechanism of microtubule assembly because they showed, contrary to expectation, that the conformation of tubulins did not change as a function the nucleotide bound.
Dr. Rice joined the faculty of UT Southwestern in the fall of 2007. His lab is broadly focused on developing a comprehensive understanding of microtubule dynamics that connects the properties of individual molecules to the complex polymerization dynamics that emerge - at different length and time scales - from collectiveinteractions among these molecules. A wide range of techniques is being used: X-ray crystallography, time-lapse microscopy, in vitro reconstitution, yeast genetics, biochemisty, computational modeling, and more.

Series Name:  Cell Biology
Videocast:  Event will not be videocast
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Thursday, January 25, 2018   11:00am - 12:00pm Add To Outlook Calendar     Add To iCal Calendar     Add To Entourage Calendar
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Name:   Luke Rice, Ph.D.
Title:   One TOG, Two TOG: Regulation of microtubule dynamics by TOG-domain proteins
Organization:   UT Southwestern Medical Center
City/Province:   dallas
State:   Texas
Country:   USA

Organization(s):  [NIH] Cell Biology Interest Group - Biology and Biophysics

Location:  On the main NIH Campus
Building:  Building 50

Name:   Karen Kendrick
Phone:   3014519223
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