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Event Type:  Seminar (This is an NIH Science event)
Title:  The mechanism of ribosome recycling and its role in protein quality control
Description:  The Proteostasis (Protein Homeostasis) Scientific Interest Group (PSIG)* will present a seminar on Tuesday, January 16, 12:00-1:00 p.m., Building 35A Room 640 (ground floor) entitled "The mechanism of ribosome recycling and its role in protein quality control" by Nick Guydosh, Ph.D. who is a Stadtman Investigator in the Laboratory of Biochemistry and Genetics, NIDDK. The goal of his research is to understand the mechanism and regulation of translation termination and how ribosomal subunits are removed from mRNAs (recycled). In particular, his work has focused on the question of how ribosomes are recycled after stalling on mRNAs that are cleaved by the endonuclease Ire1, a key factor in the unfolded protein response. His talk will also cover recent work on how ribosomes are recycled at stop codons after translation termination, the role of novel factors involved in this process, and how failure in recycling leads to translation of 3’UTRs and production of novel peptides, particularly under stress.

The seminar is open to all those interested in proteostasis and its universal role in human health and disease.

The seminar will not be videocast live or archived.

Due to current security measures at NIH, off-campus visitors are advised to consult the NIH Visitors and Security at:

For more information about the seminar please email to

*The Proteostasis Scientific Interest Group (PSIG) provides a forum to facilitate communication, and collaboration among NIH intramural and outside researchers who are working on different aspects of the Proteostasis Network. For more information about the PSIG, contact Dr. Andras Orosz at; check the Web site at; or join the LISTSERV at

Videocast:  Event will not be videocast
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Tuesday, January 16, 2018   12:00pm - 1:00pm Add To Outlook Calendar     Add To iCal Calendar     Add To Entourage Calendar
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Name:   Nick Guydosh
Title:   Ph.D.
Organization:   NIDDK, NIH
City/Province:   Bethesda
State:   Maryland
Country:   USA

Organization(s):  Proteostasis SIG

Location:  On the main NIH Campus
Building:  35
Room:  640 (ground floor)
Street Address:  9000 Rockville Pike
City:  Bethesda
State:  Maryland
Zip Code:  20892

Name:   Andras Orosz
Phone:   301-443-2193
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