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Event Type:  Lecture (This is an NIH Science event)
Annual Lecture:  Margaret Pittman Lecture
Title:  Cerebellar synaptic signaling as a metaphor for mentorship: how silence and speech get different deeds done
Description:  The cerebellum facilitates learned, coordinated movements and corrects errors. Signals to execute these functions are carried by the large neurons of the cerebellar nuclei, which form the major premotor projection from the cerebellum. How these neurons fire is determined by the interaction between their intrinsic ion channels, which favor spontaneous action potential firing; the constant barrage of synaptic inhibition they receive from dozens of convergent rapidly firing Purkinje cells; and the activity of mossy fiber inputs which excite large premotor cells directly as well as Purkinje cells indirectly. This seminar will discuss synaptic and cellular specializations in the mouse cerebellar nuclei that permit distinct modes of firing in response to different patterns of synaptic inputs as measured in vitro, as well as their relation to movements measured in awake behaving animals. The data provide evidence that not only the rate but also the temporal structure of Purkinje cell firing can influence the efficacy of synaptic excitation of large neurons, the pattern of cerebellar output, and the consequences for motor behavior.
Series Name:  Wednesday Afternoon Lecture Series
Event URL:
Videocast:  Event will be videocast LIVE on the Web
Videocast URL:
  Event will be available in the videocast ARCHIVE
Special Instructions:  Continuing Medical Education (CME) event
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Wednesday, May 02, 2018   3:00pm - 4:00pm Add To Outlook Calendar     Add To iCal Calendar     Add To Entourage Calendar
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Name:   Indira M. Raman, Ph.D.
Title:   Bill and Gayle Cook Professor
Organization:   Northwestern University

Organization(s):  [NIH] Office of the Director (OD)

Location:  On the main NIH Campus
Building:  10
Room:  Masur Auditorium

Name:   Jacqueline Roberts
Phone:   301-594-6747
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