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Event Type:  Lecture (This is an NIH Science event)
Title:  Immunology by Numbers: Quantitation of Antigen Presentation Completes the Quantitative Milieu of Systems Immunology!
Description:  The classic quantitative tools of immunology have provided critical insights into immune outcome and recent advances have now taken this to a cell specific and in some circumstances even single cell level of resolution. For example, MHC tetramers have allowed the enumeration and characterisation of epitope specific lymphocytes. More recently, the development of mass spectrometry based approaches has provided new avenues to investigate the specificity of the immune response and to address the missing gap of systems wide epitope quantitation on the surface of antigen presenting cells. I will present recent data that highlights the discovery and quantitation of anti-viral epitopes, self-epitopes and neoepitopes using next generation mass spectrometric approaches including multiple reaction monitoring and data independent acquisition (SWATH) - mass spectrometry. Within this context we have developed several novel workflows that allow simultaneous measurement of antigen expression and epitope presentation, the identification of post-translationally modified T cell epitopes and differential antigen processing that promotes T cell heterogeneity and immune evasion. Incorporation of this information into system based models facilitates the study of infectious immunity, autoimmunity and allergy at a system wide level.
Series Name:  Proteomics Interest Group Lecture Series
Videocast:  Event will not be videocast
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Tuesday, October 31, 2017   11:00am - 12:00pm Add To Outlook Calendar     Add To iCal Calendar     Add To Entourage Calendar
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Name:   Anthony W. Purcell
Title:   Ph. D
Organization:   Monash University
City/Province:   Victoria
Country:   Australia

Organization(s):  Proteomics Interest Group

Location:  On the main NIH Campus
Building:  Building 50
Room:  1328/1334
Street Address:  9000 Rockville Pike
City:  Bethesda
State:  Maryland
Zip Code:  20892

Name:   Aleksandra Nita-Lazar
Phone:   301-451-4394
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