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Event Type:  Lecture (This is an NIH Science event)
Title:  Control of Skin Immunity by Non-Immune Cells
Description:  The skin is a barrier organ that is a frequent site of entry for numerous pathogens. The skin is able to resist infection through a variety of mechanisms including innate and adaptive immune responses. Resident memory T cells (TRM) are a recently appreciated subset of memory T cells that reside in the skin and are required for optimal protection against previously encountered pathogens. These cells also participate in a number of cutaneous autoimmune diseases including vitiligo, psoriasis and alopecia areata. The skin also contains several populations innate immune cells that provide pathogen protection during the initial contact with a pathogen. Our work focuses on understanding how peripheral nerves in the skin as well as keratinocytes that form the structure of the epidermis interact with the local cutaneous immune system to provide optimal resistance to pathogens. We found that the residence of epidermal TRM and dendritic cells requires the presence of activated TGFß1. TGFß1 is secreted from several sources but, notably, the key regulated step was the obligate activation of TGFß1 by the integrins avß6 and avß8 that are expressed by keratinocytes. Antibody mediated blockade of these integrins resulted in loss of TRM from the epidermis highlighting the important function of keratinocytes in determining the epidermal occupancy TRM. We also found that pain sensing neurons in the skin can directly sense the presence of invasive C. albicans resulting in elaboration of the neuropeptide CGRP. CGPR was required for a local inflammatory cascade involving dendritic cell and TCR ?d T cell activation, the elaboration of IL-17 and ultimately host defense to C. albicans. In summary, both nerves in the skin and keratinocytes play a key role in modulating cutaneous immunity and represent novels potential therapeutic targets to augment host defense and/or suppress autoimmune diseases.
Series Name:  Immunology Interest Group Seminar Series
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Videocast:  Event will be videocast LIVE on the Web
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Wednesday, October 18, 2017   4:15pm - 5:15pm Add To Outlook Calendar     Add To iCal Calendar     Add To Entourage Calendar
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Name:   Dan Kaplan
Title:   Associate Professor of Dermatology .
Organization:   University of Pittsburgh

Organization(s):  [NIH] Immunology Interest Group

Location:  On the main NIH Campus
Building:  Building 10, Lipsett

Name:   Niki Moutsopoulos
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