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Event Type:  Seminar (This is an NIH Science event)
Title:  Accessing Cancer Cells Through Controlling Endothelial Leakiness with Nanotechnology
Description:  Biography: David Leong is an Associate Professor from the Department of Chemical and Biomolecular Engineering, National University of Singapore (NUS). He graduated with a Bachelor of Chemical Engineering and a PhD in Biology from NUS. He did his postdoctoral studies in Howard Hughes Medical Institute, University of Pennsylvania Medical School and returned to NUS as a Lee Kuan Yew Postdoctoral Fellow and later joined his alma mater department as an Asst Professor in 2010. He has contributed to diverse topics spanning from chemical synthesis to sensor development; nanosafety to nanomedicine topics.

Abstract: Cancer nano medicine strategies in the literature often rely on exploiting the enhanced endothelial permeability and retention (EPR) effect of the tumor vasculature to assess the tumor cells. However, there are several issues if there is the sole dependence on the EPR effect to access the tumor. Since the EPR effect of leaky cancer vasculature is derived from the tumor, it is unpredictable and makes sub-tumor region targeting, a hit-and-miss endeavor. Moreover, the EPR effect is initiated by a more mature tumor with more mutations which ironically carries more drug resistance. This limits any EPR dependent nanomedicine to only begin to access a more difficult to kill tumor instead of accessing and killing a less mature and more vulnerable tumor. We described several non-EPR dependent nanobiotechnological strategies with the overall future goal of accessing an immature tumor through the vasculature. We showed that we could almost induce permeability at will through tinkering with nanoparticles induced oxidative stress; through controlling the density and size parameters of nanomaterials to induce endothelial cells leakiness (NanoEL). These studies may represent a paradigm shift from a passive targeting to a more proactive and designed approach towards accessing the tumors (especially immature tumors) from the vasculature.
Series Name:  NANO SIG Seminar Series
Videocast:  Event will not be videocast
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Tuesday, August 22, 2017   11:00am - 12:00pm Add To Outlook Calendar     Add To iCal Calendar     Add To Entourage Calendar
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Name:   David Leong
Title:   Associate Professor
Organization:   National University of Singapore
Country:   Singapore

Organization(s):  [NIH] National Institute of Biomedical Imaging and Bioengineering (NIBIB)

Location:  On the main NIH Campus
Building:  35
Room:  GG607

Name:   Shawn Chen
Phone:   3014514246
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