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EVENT DESCRIPTION  
 
Event Type:  Seminar (This is an NIH Science event)
 
Title:  Identification of an Autophagy Receptor Specific for the Elimination of Protein Aggregates in Neurodegenerative Disease
 
Description:  The Proteostasis (Protein Homeostasis) Scientific Interest Group (PSIG)* will present a seminar on Monday, July 17, 12:00-1:00 p.m., 35A Room 610 (ground floor) entitled “Identification of an Autophagy Receptor Specific for the Elimination of Protein Aggregates in Neurodegenerative Disease” by Shireen Sarraf, Ph.D. who is a postdoctoral PRAT fellow in NINDS.

Clearance of misfolded proteins is essential for the maintenance of cellular homeostasis. Cellular quality control is mainly mediated by three systems: chaperone-mediated refolding, proteasomal degradation of ubiquitinated proteins and autophagy. Aggrephagy is a selective form of autophagy which targets ubiquitin-labelled protein aggregates for autophagic degradation; however, the underlying mechanisms concerning how these aggregates are recognized and targeted for degradation are not fully understood. We have found that the autophagy receptor protein, TAX1BP1, is required for the autophagic clearance of stress-induced protein aggregates, most likely acting as a bridge between ubiquitinated cargo protein and the autophagy machinery. Furthermore, TAX1BP1 colocalizes with and contributes to the clearance of the ALS-associated protein, TDP-43, in cells and neuronal culture.

Title: Identification of an Autophagy Receptor Specific for the Elimination of Protein Aggregates in Neurodegenerative Disease
Date: Monday, July 17, 2017
Time: 12:00 pm - 1:00 pm
Location: 35A Room 610 (ground floor), National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892

The seminar is open to all those interested in proteostasis and its universal role in human health and disease.

The seminar will not be videocast live or archived.

Due to current security measures at NIH, off-campus visitors are advised to consult the NIH Visitors and Security at: http://www.nih.gov/about/visitorsecurity.htm.

For more information about the seminar please email to orosza@mail.nih.gov. Individuals with disabi
 
Videocast:  Event will not be videocast
 
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of Research Services (ORS) Interpreting Service Requests web page.
 

EVENT DATE/TIME  
 
Date/Time: 
Monday, July 17, 2017   12:00pm - 1:00pm Add To Outlook Calendar     Add To iCal Calendar     Add To Entourage Calendar
 
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EVENT SPEAKER(S)  
 
Name:   Dr. Shireen Sarraf
Title:   Identification of an Autophagy Receptor Specific for the Elimination of Protein
Organization:   NINDS, NIH
City/Province:   Bethesda
State:   Maryland
Country:   USA
 

EVENT SPONSOR(S)  
 
Organization(s):  Proteostasis Scientific Interest Group
 

EVENT LOCATION  
 
Location:  On the main NIH Campus
Building:  35A
Room:  Room 610 (ground floor)
 
Street Address:  9000 Rockville Pike
City:  Bethesda
State:  Maryland
Zip Code:  20892
 

EVENT CONTACT(S)  
 
Name:   Andras Orosz
E-mail:   orosza@mail.nih.gov
Phone:   13014432193
 
 
 
 
 
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