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Event Type:  Seminar (This is an NIH Science event)
Title:  Law of STAT Fives, Root Orchestrators of Lymphocyte Homeostasis and Function
Description:  The transcription factor STAT5 is fundamental to the mammalian immune system. Operating downstream of cytokines and growth factors, it impacts all aspects of lymphocyte biology, from general cellular processes like proliferation and apoptosis, to specialized immunological programs like effector and regulatory T cell differentiation. Genetic studies in humans underscore its widespread influence as mutations of STAT5 or upstream activators manifest varied immunological phenotypes including immunodeficiency, autoimmunity and hematological malignancies. Mouse models of STAT5 deficiency have affirmed these findings and have been instrumental in defining its broad homeostatic and metabolic functions, as well as lineage-restricted pro- and anti-inflammatory capabilities. Coupled to high-throughput sequencing technologies, they have also enabled genome-wide discovery of STAT5-dependent gene networks in both innate and adaptive lymphocytes, and have yielded valuable mechanistic insights on how it instructs gene transcription. Ongoing research will further clarify how STAT5 works at cellular, molecular and genomic levels with the overarching goal of informing the development of therapeutic agents to target STAT5 and/or relevant downstream targets.
Series Name:  Immunology Interest Group Seminar Series
Videocast:  Event will be videocast LIVE on the Web
Videocast URL:
  Event will be available in the videocast ARCHIVE
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Wednesday, June 28, 2017   4:15pm - 5:30pm Add To Outlook Calendar     Add To iCal Calendar     Add To Entourage Calendar
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Name:   Dr. Alejandro Villarino
Organization:   NIAMS/NIH
City/Province:   Bethesda
State:   Maryland
Country:   United States

Organization(s):  [NIH] Immunology Interest Group

Location:  On the main NIH Campus
Building:  Building 10
Room:  Lipsett Amphitheater
Street Address:  9000 Rockville Pike
City:  Bethesda
State:  Maryland
Zip Code:  20892

Name:   Vanja Lazarevic
Phone:   3014516882
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