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Event Type:  Seminar (This is an NIH Science event)
Annual Lecture:  Other
Title:  Interaction of Membrane Cholesterol with G Protein-Coupled Receptors: Novel Insights in Health and Disease
Description:  Interaction of Membrane Cholesterol with G Protein-Coupled Receptors: Novel Insights in Health and Disease

Prof. Amitabha Chattopadhyay
Centre for Cellular and Molecular Biology, Uppal Road, Hyderabad, India

G protein-coupled receptors (GPCRs) are the largest class of molecules involved in signal transduction across membranes, and represent major drug targets in all clinical areas. The serotonin1A receptor is an important neurotransmitter receptor of the GPCR superfamily and is implicated in the generation and modulation of various cognitive, behavioral and developmental functions. We previously demonstrated that membrane cholesterol is necessary for ligand binding, and G-protein coupling of serotonin1A receptors. Interestingly, recently reported crystal structures of GPCRs have shown structural evidence of cholesterol binding site(s). In this context, we reported the presence of cholesterol recognition/interaction amino acid consensus (CRAC) motifs in the serotonin1A receptor. We also showed that the receptor is more stable and compact in the presence of membrane cholesterol. Our recent results utilizing coarse-grain molecular dynamics simulations to analyze the molecular nature of receptor-cholesterol interaction offer interesting insight in cholesterol binding site(s) in the receptor and oligomerization of the receptor. We showed utilizing homo-FRET that the serotonin1A receptor is constitutively oligomerized in live cells, with the possibility of higher order oligomers of the receptor. Progress in deciphering molecular details of the nature of GPCR-cholesterol interaction in the membrane would lead to better insight into our overall understanding of GPCR function in health and disease.
Videocast:  Event will not be videocast
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Tuesday, July 18, 2017   1:30pm - 2:30pm Add To Outlook Calendar     Add To iCal Calendar     Add To Entourage Calendar
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Name:   Prof. Amitabha Chattopadhyay
Title:   J.C. Bose Fellow
Organization:   Centre for Cellular and Molecular Biology
City/Province:   Hyderabad
Country:   India

Organization(s):  [NIH] National Cancer Institute (NCI) - RNA Biology Laboratory & Cancer and Developmental Biology Laboratory

Location:  Off Campus
Building:  NCI at Frederick, Building 426
Room:  Conference Room 103
Street Address:  Miller Drive
City:  Frederick
State:  Maryland
Zip Code:  21702

Name:   Kimberly Mellon
Phone:   301-228-4628
Fax:   301-846-7117
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