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Event Type:  Lecture (This is an NIH Science event)
Annual Lecture:  Other
Title:  Imaging the Lesion in Multiple Sclerosis
Description:  Imaging the Lesion in Multiple Sclerosis

Daniel S. Reich, MD, PhD
NIH Director’s Seminar
June 16, 2017

Does the white matter lesion in multiple sclerosis (MS) still matter in the age of highly effective disease-modifying therapy, which acts primarily to stop new lesions from forming? Evidence suggests that it does – not just because the most effective therapies are also the riskiest, but also because therapies that stop new lesions from forming do not appear to impact chronic inflammation or enhance repair. In this seminar, I will discuss our lab’s findings from the past few years about the development and early repair of white matter lesions in MS, and how those findings are mirrored in inflammatory demyelinating lesions in a primate model of MS. I will describe pathological changes that occur prior to demyelination and show how failed early repair can lead to smoldering inflammation at the lesion edge, with its attendant slow myelin destruction. I will also report on our progress in imaging the recently described meningeal lymphatic system.

Series Name:  NIH Director's Seminar Series
Videocast:  Event will be videocast LIVE on the Web
Videocast URL:
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Friday, June 16, 2017   12:00pm - 1:00pm Add To Outlook Calendar     Add To iCal Calendar     Add To Entourage Calendar
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Name:   Daniel S. Reich, MD, PhD
Title:   Chief, Translational Neuroradiology Unit
Organization:   Neuroimmunology Branch, NINDS

Organization(s):  [NIH] Office of the Director (OD)

Location:  On the main NIH Campus
Building:  35A
Room:  640
Street Address:  35A Convent Drive
City:  Bethesda
State:  Maryland
Zip Code:  20892

Name:   Margaret McBurney
Phone:   (301) 496-1921
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