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Event Type:  Seminar (This is an NIH Science event)
Annual Lecture:  Other
Title:  Imaging Immunity – Developing a Spatiotemporal Understanding of Host Defense Using Intravital Dynamic and Multiplex Static Microscopy
Description:  Major biological processes rely on the precise positioning of diverse cell types in specific anatomical locations. The immune system in particular has requirements not only for cell positioning but for rapid organized changes in cell number and location in response to insults to the organism. In this lecture Ron Germain will describe advances in understanding innate and adaptive immune responses made in the Lymphocyte Biology Section of the Laboratory of Systems Biology through the application of dynamic intravital 2P imaging and also using a new technology for static imaging that enables highly multiplex staining and quantitative analysis of diverse cell types tissue sections, a method called Histo-cytometry. He will also present a new easy-to-use and inexpensive tissue clearing technique for attaining high-quality images of cells and diverse molecules of interest in substantial tissue volumes, enabling simultaneous quantitative analysis of 3D organ structure and fine-grained cellular composition. This latter technology will enhance our capacity for acquiring a quantitative understanding of the relationships between cells and their microenvironments in the context of broader tissue organization and is directly applicable to diverse biological disciplines as well as diagnostic medicine.
1. Gerner MY, Kastenmuller W, Ifrim I, Kabat J, Germain RN. Histo-cytometry: a method for highly multiplex quantitative tissue imaging analysis applied to dendritic cell subset microanatomy in lymph nodes. Immunity. 2012 Aug 24;37(2):364-76.
2. Germain RN, Robey EA, Cahalan MD. A decade of imaging cellular motility and interaction dynamics in the immune system. Science. 2012 Jun 29;336(6089):1676-81.
3. Lämmermann T, Afonso PV, Angermann BR, Wang JM, Kastenmüller W, Parent CA, Germain RN. Neutrophil swarms require LTB4 and integrins at sites of cell death in vivo. Nature. 2013 Jun 20;498(7454):371-5.
4. Gerner MY, Torabi-Parizi P, Germain RN. Strategically localized
Series Name:  Light Microscopy Interest Group Seminar
Videocast:  Event will not be videocast
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Tuesday, June 20, 2017   11:00am - 12:00pm Add To Outlook Calendar     Add To iCal Calendar     Add To Entourage Calendar
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Name:   Ronald Germain
Title:   DR
Organization:   NIH/NIAID
City/Province:   Bethesda
State:   Maryland
Country:   USA

Organization(s):  [NIH] Light Microscopy Interest Group

Location:  On the main NIH Campus
Building:  37
Room:  4107/4041
Street Address:  37 Convent Drive
City:  Bethesda
State:  Maryland
Zip Code:  20892

Name:   Tatiana S. Karpova
Phone:   2407606637
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