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Event Type:  Seminar (This is an NIH Science event)
Title:  The Plasticity and Migratory Responses of Innate Lymphoid Cells: More Similarity to T Cells than you Thought
Description:  The identification of innate lymphoid cells (ILCs) was a major step forward in developing a better understanding of host defense. Although ILC lack the capacity for antigen recognition, they show striking similarities with T cell subsets in both the transcription factors that govern their differentiation and the effector cytokines they produce. One major difference in the existing concepts of ILC and adaptive T cell responses is that the former are considered to act largely as tissue resident effectors whereas T cells migrate from secondary lymphoid tissues of activation to peripheral tissue locations where they mediate effector activity. However, our studies suggest that ILCs may share a greater relationship with T cells in terms of biology than previously considered. Our analysis of inflammatory ILC2 cells revealed that after activation in the intestinal lamina propria upon IL-25, these iILC2s entered the lymphatic and then blood circulation in an S1P-depndent manner, migrating to lung and other peripheral sites where they mediate crucial protection during helminthic infection. These data suggest that the current paradigm of local activation and distant function for T cell-mediated immunity actually borrows from a mode of operation already present in innate lymphoid cell populations prior to development of antigen specific host defenses.
Series Name:  Immunology Interest Group Seminar Series
Videocast:  Event will be videocast LIVE on the Web
Videocast URL:
  Event will be available in the videocast ARCHIVE
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Wednesday, June 07, 2017   4:15pm - 5:15pm Add To Outlook Calendar     Add To iCal Calendar     Add To Entourage Calendar
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Name:   Dr. Yuefeng Huang
Organization:   National Institute of Allergy and Infectious Diseases
City/Province:   Bethesda
State:   Maryland
Country:   United States

Organization(s):  [NIH] Immunology Interest Group

Location:  On the main NIH Campus
Building:  Building 10
Room:  Lipsett Amphitheater
Street Address:  9000 Rockville Pike
City:  Bethesda
State:  Maryland
Zip Code:  20892

Name:   Vanja Lazarevic
Phone:   3014516882
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