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Event Type:  Seminar (This is an NIH Science event)
Title:  Lipidic Cubic Phase Technologies for Structural Studies of Membrane Proteins
Description:  Lipidic cubic phase (LCP) represents a membrane-mimetic matrix with unique properties. It has been successfully used for stabilization and crystallization of challenging membrane proteins, such as G protein-coupled receptors (GPCRs), the structure of which is often difficult to obtain by other methods. Multiple advancements in the development of tools and instruments for LCP crystallization over the last decade have been aimed at facilitating the research in this area and helping structural biologists with integrating these technologies in their working routine. As a result, LCP crystallization is gaining momentum, with about quarter of all new membrane protein structures currently being produced by this method. Recently LCP has been adapted as a growth and delivery matrix for microcrystals of GPCRs and other membrane and soluble proteins to significantly reduce the amount of material required for room temperature data collection by emerging technique of Serial Femtosecond Crystallography (SFX) at X-ray Free Electron Lasers (XFELs).
Videocast:  Event will not be videocast
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Friday, May 19, 2017   2:00pm - 3:00pm Add To Outlook Calendar     Add To iCal Calendar     Add To Entourage Calendar
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Name:   Vadim Cherezov, Ph.D.
Title:   Professor
Organization:   University of Southern California
City/Province:   Los Angeles
State:   California
Country:   USA

Organization(s):  Structure Biology Interest Group (SBIG)

Location:  On the main NIH Campus
Building:  Building 35A
Room:  640
Street Address:  35 Convent Drive
City:  Bethesda
State:  Maryland
Zip Code:  20892

Name:   Katrina Matthews
Phone:   301-496-5039
Fax:   301-402-9319
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