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EVENT DESCRIPTION  
 
Event Type:  Seminar (This is an NIH Science event)
 
Annual Lecture:  Other
 
Title:  Co-alignment and Orientation of Activated Integrins in Focal Adhesions of Migrating Cells Studied by Fluorescence Polarization
 
Description:  Integrins are adhesion receptors linking cells to the environment and function as sensors of physical and chemical information to regulate development, immune response, and vascular function. How integrin mediated focal adhesions decode directional information including fluid flow or tissue tension has remained elusive. We have used polarization-based microscopy techniques to discover that activated integrins are aligned with one another in focal adhesions in migrating fibroblasts. Integrin co-alignment is sensitive to mechanical resistance of its ligand and coupling to a dynamic actin cytoskeleton, consistent with the “lateral force” integrin activation model. Our work suggests that activated integrins are actively ordered at the molecular scale by cellular forces, which may underlie their ability to sense directional forces in their environment to mediate critical physiological functions. Here, I will discuss our application of fluorescence polarization microscopy techniques to measure integrin alignment and orientation as well as briefly discuss the potential application of this technique in studying other macromolecular assemblies in cells.
 
Series Name:  Light Microscopy Interest Group Seminar
 
Videocast:  Event will not be videocast
 
Special Instructions:  To arrange sign language interpretation for an event go to the Office
of Research Services (ORS) Interpreting Service Requests web page.
 

EVENT DATE/TIME  
 
Date/Time: 
Tuesday, May 16, 2017   11:00am - 12:00pm Add To Outlook Calendar     Add To iCal Calendar     Add To Entourage Calendar
 
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EVENT SPEAKER(S)  
 
Name:   Vinay Swaminathan
Title:   Dr
Organization:   NIH/NHLBI
City/Province:   Bethesda
State:   Maryland
Country:   USA
 

EVENT SPONSOR(S)  
 
Organization(s):  [NIH] Light Microscopy Interest Group
 

EVENT LOCATION  
 
Location:  On the main NIH Campus
Building:  37
Room:  4107/4041
 
Street Address:  37 Convent Drive
City:  Bethesda
State:  Maryland
Zip Code:  20892
 

EVENT CONTACT(S)  
 
Name:   Tatiana Karpova
E-mail:   karpovat@mail.nih.gov
Phone:   240-760-6637
Fax:   240-541-4450
 
 
 
 
 
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