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Event Type:  Seminar (This is an NIH Science event)
Annual Lecture:  Other
Title:  Co-alignment and Orientation of Activated Integrins in Focal Adhesions of Migrating Cells Studied by Fluorescence Polarization
Description:  Integrins are adhesion receptors linking cells to the environment and function as sensors of physical and chemical information to regulate development, immune response, and vascular function. How integrin mediated focal adhesions decode directional information including fluid flow or tissue tension has remained elusive. We have used polarization-based microscopy techniques to discover that activated integrins are aligned with one another in focal adhesions in migrating fibroblasts. Integrin co-alignment is sensitive to mechanical resistance of its ligand and coupling to a dynamic actin cytoskeleton, consistent with the “lateral force” integrin activation model. Our work suggests that activated integrins are actively ordered at the molecular scale by cellular forces, which may underlie their ability to sense directional forces in their environment to mediate critical physiological functions. Here, I will discuss our application of fluorescence polarization microscopy techniques to measure integrin alignment and orientation as well as briefly discuss the potential application of this technique in studying other macromolecular assemblies in cells.
Series Name:  Light Microscopy Interest Group Seminar
Videocast:  Event will not be videocast
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of Research Services (ORS) Interpreting Service Requests web page.

Tuesday, May 16, 2017   11:00am - 12:00pm Add To Outlook Calendar     Add To iCal Calendar     Add To Entourage Calendar
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Name:   Vinay Swaminathan
Title:   Dr
Organization:   NIH/NHLBI
City/Province:   Bethesda
State:   Maryland
Country:   USA

Organization(s):  [NIH] Light Microscopy Interest Group

Location:  On the main NIH Campus
Building:  37
Room:  4107/4041
Street Address:  37 Convent Drive
City:  Bethesda
State:  Maryland
Zip Code:  20892

Name:   Tatiana Karpova
Phone:   240-760-6637
Fax:   240-541-4450
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