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Event Type:  Seminar (This is an NIH Science event)
Annual Lecture:  Other
Title:  Insights from a Novel Model of Dry AMD
Description:  Here, we show that Wnt and Nrf2, two fundamental signaling systems that are vital to cell survival, decline in a novel model of geographic atrophy, in a bidirectional feedback loop through phosphorylated GSK3ß. Decreased Wnt and Nrf2 signaling leads to RPE dysfunction and apoptosis, and a phenotype that is strikingly similar to geographic atrophy, an advanced form of AMD with no effective treatment. We also show STGD have increased BrM-EZ and BrM-RPE thickness and thining of EZ in areas that are devoid o atrophy and flecks. The BrM-EZ segment of the outer-retina of STGD lacked the typical normal tri-laminar pattern. These findings suggest that pathologic changes in STGD are more widespread than that seen by clinical examination.
Videocast:  Event will not be videocast
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Thursday, April 27, 2017   12:00pm - 1:00pm Add To Outlook Calendar     Add To iCal Calendar     Add To Entourage Calendar
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Name:   Katayoon Baradaran Ebrahimi, M.D.
Organization:   Duke Eye Institute, Duke University
City/Province:   Durham
State:   North Carolina
Country:   United States

Organization(s):  [NIH] National Eye Institute (NEI)

Location:  On the main NIH Campus
Building:  10
Room:  10N202 (Cogan)

Name:   Mica Gordon
Phone:   301-451-6763
Fax:   301-451-6764
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