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Event Type:  Seminar (This is an NIH Science event)
Title:  Glia Modulate the Shape and Function of Neuron Receptive-endings
Description:  In nervous systems, glia approximate neurons in number, associate closely with them and are implicated in many neurodevelopmental disorders including childhood brain cancers and autism. However, glial functions in nervous system development and function are poorly understood at molecular resolution. Using C. elegans as a model, I identified a novel mechanism where glia regulate the shape and function of a neuron-ending by modulating its specific ionic micro-environment. All components of the underlying molecular pathway, which I identified, are broadly conserved and therapeutically relevant. Glia are also known to engulf neuronal fragments in mammals, but the molecular mechanisms regulating this process are unclear. I discovered that C. elegans glia engulf neuronal fragments as well, which establishes C. elegans as a new model for studying this evolutionarily conserved and disease-relevant function of glial cells.
Videocast:  Event will not be videocast
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Monday, April 17, 2017   9:00am - 10:00am Add To Outlook Calendar     Add To iCal Calendar     Add To Entourage Calendar
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Name:   Aakanksha Singhvi, Ph.D.
Title:   Postdoctoral Fellow
Organization:   The Rockefeller University
City/Province:   New York City
State:   New York
Country:   USA

Organization(s):  Cellular and Developental Neurobiology, NICHD

Location:  On the main NIH Campus
Building:  John Edward Porter Neuroscience Research Center,
Room:  Building 35A, Room GG607 (Ground Level)
Street Address:  35 Convent Drive
City:  Bethesda
State:  Maryland
Zip Code:  20892

Name:   Katrina Matthews
Phone:   301-496-5039
Fax:   301-402-9319
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