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Event Type:  Lecture
Annual Lecture:  Other
Title:  Of Dogs and Men: The Red Cell Storage Lesion
Description:  Abstract
The advent of preservative solutions permitted refrigerated storage of red cells (RBCs), however the convenience of having RBC inventories was accompanied by a disadvantage: red cells undergo numerous physical and metabolic changes during cold storage, the “storage lesion(s)”. Whereas controlled clinical trials have not confirmed the clinical importance of such changes, ethical and operational issues have prevented careful study of the oldest stored RBCs. Suggestions of toxicity from meta-analyses motivated us to develop preclinical canine models to compare the freshest vs. oldest RBCs. Our model of canine pneumonia with RBC transfusion indicated that the oldest RBCs increased mortality, that the severity of pneumonia is important, but that the dose of transfused RBCs is not. Washing the oldest RBCs reduces mortality by removing senescent cells and remnants, whereas washing fresher cells increases mortality by damaging the RBC membrane. An opposite effect was found in a model of hemorrhagic shock with reperfusion injury. Physiologic studies indicate that release of iron from old cells is a primary mechanism of toxicity during infection, whereas scavenging of cell free hemoglobin may be beneficial during reperfusion injury. Intravenous iron appears to have toxicity equivalent to old RBCs in the pneumonia model, suggesting that IV iron and old RBCs should be administered with caution to infected patients. Based on these studies, the NIH Clinical Center has limited the RBC storage period to 35 days.
Series Name:  Annual Jamieson Lecture
Videocast:  Event will not be videocast
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Thursday, May 04, 2017   11:00am - 12:30pm Add To Outlook Calendar     Add To iCal Calendar     Add To Entourage Calendar
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Name:   Harvey G. Klein, MD
Title:   Chief, Department of Transfusion Medicine
Organization:   National Institutes of Health
City/Province:   Bethesda
State:   Maryland
Country:   USA

Organization(s):  American Red Cross/Holland Lab

Location:  Off Campus
Building:  American Red Cross Holland Laboratory
Room:  C109
Street Address:  15601 Crabbs Branch Way
City:  Rockville
State:  Maryland
Zip Code:  20855
Other Information:  Free Parking

Name:   Stephen J. Wagner, PhD
Phone:   240-314-3497
Fax:   301-610-4116
Name:   Faezeh Lotfalian
Phone:   240-314-3496
Fax:   301-610-4116
Name:   Gary Moroff, PhD
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