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Event Type:  Seminar (This is an NIH Science event)
Title:  A Two-Pronged Attack on Host Transcription by Influenza Virus
Description:  We have used mammalian native elongating transcript sequencing (mNET-seq) to profile host RNA polymerase II transcription across the genome during influenza infection: we observe dramatic changes to Pol II transcription (1) in the bodies of genes and (2) in termination. (1) Both influenza A & B infection deplete Pol II from the bodies of protein-coding genes, likely due to cap-snatching activity; IAV (but not IBV) depletes Pol II from lincRNA genes, suggesting different targeting specificities for Pol II by the viral polymerases; (2) both IAV and IBV cause a Pol II termination defect that results in run-on transcription, sometimes for 10-100 kb. This defect is present only on genes subject to canonical 3’-end processing. While we find the NS1 protein from A/WSN alone is capable of inducing a termination defect due to its strong interaction with CPSF30, both A/PR8 — which has an attenuated NS1-CPSF30 interaction — and IBV — which has no reported NS1-CPSF30 interaction — still cause a defect in transcription termination, suggesting influenza has evolved multiple mechanisms for targeting 3’-end processing.
Videocast:  Event will not be videocast
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Tuesday, April 11, 2017   12:00pm - 1:00pm Add To Outlook Calendar     Add To iCal Calendar     Add To Entourage Calendar
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Name:   David Bauer
Organization:   Fodor Lab, Oxford Univervsity
City/Province:   Oxford
Country:   UK

Organization(s):  Laboratory of Viral Diseases, NIAID

Location:  On the main NIH Campus
Building:  Bldg 33
Room:  1N01

Name:   jon yewdell
Phone:   301 301 4602
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