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Event Type:  Seminar (This is an NIH Science event)
Title:  Inhibitory Circuit Gating of Auditory Cortical Plasticity
Description:  Cortical sensory maps are remodeled during early life to adapt to the surrounding environment. Both sensory and contextual signals are important in sculpting these developing maps, but how these inputs converge within thalamocortical circuits to trigger plasticity remains unknown. Our work reveals a layer (L) 1 map in primary auditory cortex (A1) where topographically-organized thalamic and neuromodulatory inputs converge to tune the cortical layers below. The inhibitory interneurons residing in this layer send narrowly descending projections to L4, creating temporally-precise windows of disinhibition within sound frequency columns. Notably, silencing these interneurons abolishes tonotopic map plasticity in L4 during a developmental critical period, and changes in the cholinergic activation of these interneurons control when this plasticity occurs. These findings have paved a novel research avenue by identifying L1 interneurons as key integrators of contextual and sensory signals that alter network activity and promote specific plasticity. Understanding how and when this L1 map is activated throughout life will provide insights into educational and therapeutic strategies to promote cortical plasticity.
Videocast:  Event will not be videocast
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Friday, March 17, 2017   11:00am - 12:00pm Add To Outlook Calendar     Add To iCal Calendar     Add To Entourage Calendar
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Name:   Anne E. Takesian, Ph.D.
Title:   Postdoctoral Fellow
Organization:   Boston Children’s Hospital & Harvard Medical School
City/Province:   Boston
State:   Massachusetts
Country:   USA

Organization(s):  Cellular & Developmental Neurobiologist, NICHD

Location:  On the main NIH Campus
Building:  John Edward Porter Neuroscience Research Center
Room:  Buildng 35, Room GG607
Street Address:  35 Convent Drive
City:  Bethesda
State:  Maryland
Zip Code:  20892

Name:   Katrina Matthews
Phone:   301-496-5039
Fax:   301-402-9319
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