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Event Type:  Seminar (This is an NIH Science event)
Title:  Proteomic Instability of Cancer: HSF1 is a Guardian of Cancer Proteostasis
Description:  The Proteostasis (Protein Homeostasis) Scientific Interest Group (PSIG)* will present a seminar on Tuesday, May 16, 12:00-1:00 p.m., Building 35A Room 610 (ground floor) entitled " Proteomic Instability of Cancer: HSF1 is a Guardian of Cancer Proteostasis " by Chengkai Dai, Ph.D. who is a Stadtman Tenure-Track Investigator at the Mouse Cancer Genetics Program, Center for Cancer Research, NCI. The long-term goal of his laboratory is to understand the role of proteostasis in tumorigenesis, to illuminate the new phenomenon of proteomic instability of cancer, and to exploit disrupting proteostasis as an anti-cancer therapeutic strategy. His recent work has focused on elucidating the potent pro-oncogenic role of heat shock factor 1 (HSF1), the master transcriptional regulator of the proteotoxic stress response (PSR) that critically preserves cellular proteostasis under stresses. In this talk, he will discuss how HSF1 represses tumor-suppressive amyloidogenesis, supports mTORC1 and its mediated protein synthesis, and promotes lipogenesis, thereby enabling robust oncogenesis.

Title: Proteomic Instability of Cancer: HSF1 is a Guardian of Cancer Proteostasis
Date: Tuesday, May 16, 2017
Time: 12:00 pm - 1:00 pm
Location: Building 35A Room 610 (ground floor), National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892

The seminar is open to all those interested in proteostasis and its universal role in human health and disease.

The seminar will not be videocast live or archived.

Due to current security measures at NIH, off-campus visitors are advised to consult the NIH Visitors and Security at:

For more information about the seminar please email to Individuals with disabilities who need sign language interpreters and/or reasonable accommodation to participate in this event should contact Dr. Andras Orosz (301-443-2193) and/or the Federal Relay (800-877-833
Videocast:  Event will not be videocast
Special Instructions:  To arrange sign language interpretation for an event go to the Office
of Research Services (ORS) Interpreting Service Requests web page.

Tuesday, May 16, 2017   12:00pm - 1:00pm Add To Outlook Calendar     Add To iCal Calendar     Add To Entourage Calendar
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Name:   Chengkai Dai
Title:   Ph.D.
Organization:   Center for Cancer Research, NCI, NIH
City/Province:   Frederick
State:   Maryland
Country:   USA

Organization(s):  Proteostasis SIG

Location:  On the main NIH Campus
Building:  Building 35A
Room:  Room 610 (ground floor)
Street Address:  9000 Rockville Pike
City:  Bethesda
State:  Maryland
Zip Code:  20892

Name:   Andras Orosz
Phone:   13014432193
Fax:   301-594-0673
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