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Event Type:  Seminar (This is an NIH Science event)
Title:  How to Neutralize TGFß/BMP Ligands
Description:  TGFß and BMP ligands have fundamental and diverse roles in multiple aspects of development and tissue homeostasis. For example, in muscle myostatin or GDF8 functions as an inhibitor to muscle mass where mutations in the gene or injection of myostatin inhibitors result in a double muscle phenotype. While the TGFß family is diverse consisting of 33 ligands only a handful of signaling receptors exist. Therefore, an important mechanism for regulating the bioactivity of TGFß and BMP signaling is the presence of extracellular protein modulators, which bind and block receptor interactions. While BMP and other TGFß ligands share a similar fold, extracellular antagonists are structurally diverse ranging from small single domain proteins (Noggin, DAN) to larger multi-domain antagonists (e.g. Follistatin, Chordin, GASP). Over the years structures of Noggin, Follistatin and CV-2 have demonstrated that multiple strategies have evolved to block ligand signaling. The seminar will compare and contrast the different molecular strategies that have evolved to block TGFß family ligands with an emphasis on understanding ligand specificity.

Series Name:  N/A
Videocast:  Event will not be videocast
Special Instructions:  To arrange sign language interpretation for an event go to the Office
of Research Services (ORS) Interpreting Service Requests web page.

Wednesday, March 08, 2017   2:00pm - 4:00pm Add To Outlook Calendar     Add To iCal Calendar     Add To Entourage Calendar
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Name:   Tom Thompson, Ph.D.
Title:   Professor
Organization:   Univerrsity of Cincinnati College of Medicine
City/Province:   Cincinnati
State:   Ohio
Country:   USA

Organization(s):  Cell Biology and Neurobiology Branch/Rooms 1201/1203 - Section on Cellular Communication

Location:  On the main NIH Campus
Building:  Building 40
Street Address:  40 Convent Drive/Rooms 1201/1203
City:  Bethesda
State:  Maryland
Zip Code:  20892

Name:   Katrina Matthews
Phone:   301-496-5039
Fax:   301-402-9319
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