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EVENT DESCRIPTION  
 
Event Type:  Seminar (This is an NIH Science event)
 
Title:  Aire: New Tricks from an Old Dog
 
Description:  Aire is a transcriptional regulator that controls immunological tolerance. Its primary modus operandi is the induction – specifically in thymic medullary epithelial cells – of a battery of transcripts encoding proteins characteristic of terminally differentiated peripheral cell-types, and consequently negative selection of T cells that recognize these proteins. After briefly reviewing the classical findings, this presentation will focus on more recently discovered facets of Aire function, including positive selection of a perinatal population of regulatory T cells, inhibition of the generation of IL-17-producing “early-responder” ?:d T cell populations, and activation of MEC superenhancers.
 
Videocast:  Event will be videocast LIVE on the Web
 
Videocast URL:  http://videocast.nih.gov
 
Special Instructions:  To arrange sign language interpretation for an event go to the Office
of Research Services (ORS) Interpreting Service Requests web page.
 

EVENT DATE/TIME  
 
Date/Time: 
Wednesday, March 01, 2017   4:15pm - 5:30pm Add To Outlook Calendar     Add To iCal Calendar     Add To Entourage Calendar
 
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EVENT SPEAKER(S)  
 
Name:   Dr. Diane Mathis
Title:   Professor of Microbiology and Immunobiology
Organization:   Harvard Medical School
City/Province:   Boston
State:   Massachusetts
Country:   USA
 

EVENT SPONSOR(S)  
 
Organization(s):  [NIH] Immunology Interest Group
 

EVENT LOCATION  
 
Location:  On the main NIH Campus
Building:  Building 10
Room:  Lipsett Amphitheater
 
Street Address:  9000 Rockville Pike
City:  Bethesda
State:  Maryland
Zip Code:  20892
 

EVENT CONTACT(S)  
 
Name:   Vanja Lazarevic
E-mail:   lazarevicv@mail.nih.gov
Phone:   3014516882
 
 
 
 
 
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