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Event Type:  Seminar (This is an NIH Science event)
Title:  Random Walk in the Realm of Chromatin
Description:  Development of the chromosome conformation capture (3C) technique and its progress from probing the interactions between loci to whole genome interactions (Hi-C) allowed us to enter an uncharted field of the chromatin structure, dynamics, and epigenetic regulation. Existing computational approaches for the Hi-C data analysis can be roughly classified into two categories, model-driven and data-driven, where the former is generally aimed at explaining features of the Hi-C data on the basis of proposed physical model and the latter seeks to extract information about structure and interactions. Our goal is to explore chromatin structure using a minimum of simplifying assumptions on the structure and heuristic tuning parameters in the analysis. We rely on the notion of metastability in the identification of chromatin regions that act as hubs in the landscape of interactions. Assuming the diffusive character of the chromatin local contact formation, we construct a Markov jump process that allows one to study chromatin organization. Specifically, the Markov jump process mimics a random walk in the chromatin media, where hubs correspond to highly interacting loci and provide a foundation for the reconstruction of chromatin’s organization. We show the existence of a structural hierarchy in chromatin, describe a relationship between the intra-/interchromosomal interactions and different expression signal and epigenetic factor, and discuss future tasks in the study of chromatin structure in relation to gene expression and its regulation.
Videocast:  Event will not be videocast
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Friday, February 17, 2017   11:00am - 12:00pm Add To Outlook Calendar     Add To iCal Calendar     Add To Entourage Calendar
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Name:   Igor Berezovsky
Title:   Principle Investigator
Organization:   Bioinformatics Institute
Country:   Singapore

Organization(s):  [NIH] National Library of Medicine (NLM)

Location:  On the main NIH Campus
Building:  Building 38A (Lister Hill National Center)
Room:  B2N14
Street Address:  38A Library Drive
City:  Bethesda
State:  Maryland
Zip Code:  20892

Name:   Anna Panchenko
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